Sevoflurane USP Related Compound C

Sevoflurane USP Related Compound C - Names and Identifiers

Name	1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms	HFIP C3H2F6O JACS-920-66-1 Hexafluoroisopropanol 2H-Hexafluoroisopropano 2-Propanol, hexafluoro- 2H-hexafluoro-2-propanol 2H-Hexafluoroisopropanol Hexafluoroisopropyl alcohol Bis(trifluoromethyl)methanol 1,1,1,3,3,3-hexafluoro-2-propano 1,1,1?,3,3-Hexafluoro-2-propanol 1,1,1,3,3,3-Hexafluoroisopropanol 1,1,1,2,3,3-hexafluoropropan-2-ol 1,1,1,3,3,3-Hexafluoro-2-propanol Sevoflurane USP Related Compound C 2,2,2-Trifluoro-1-(trifluoromethyl)ethanol Ethanol, 2,2,2-trifluoro-1-(trifluoromethyl)- (2,3,4,5,6-pentafluorophenyl) pyrimidine-5-carboxylate 1,1,1,3,3,3-hexafluoro-2-propanolakahfip,hexafluoroisopropanol
CAS	920-66-1
EINECS	213-059-4
InChI	InChI=1/C11H3F5N2O2/c12-5-6(13)8(15)10(9(16)7(5)14)20-11(19)4-1-17-3-18-2-4/h1-3H
InChIKey	BYEAHWXPCBROCE-UHFFFAOYSA-N

Sevoflurane USP Related Compound C - Physico-chemical Properties

Molecular Formula	C3H2F6O
Molar Mass	168.04
Density	1.596g/mLat 25°C(lit.)
Melting Point	−4°C(lit.)
Boling Point	59°C(lit.)
Flash Point	4,4°C
Water Solubility	1000 g/L (25 ºC)
Solubility	Soluble in water (1000 mg/ml at 25 °C), chloroform, ether, and acetone.
Vapor Presure	269 hPa (30 °C)
Appearance	Transparent liquid
Specific Gravity	1.596
Color	White to yellow
Maximum wavelength(λmax)	['229nm(lit.)']
BRN	1841007
pKa	pK1:9.42 (25°C)
PH	3-4 (H2O)Aqueous solution
Storage Condition	Store below +30°C.
Stability	Stable. Incompatible with strong acids, strong bases, alkali metals.
Refractive Index	n20/D 1.275(lit.)
MDL	MFCD00011651

Sevoflurane USP Related Compound C - Risk and Safety

Risk Codes	R20/22 - Harmful by inhalation and if swallowed. R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing.
UN IDs	UN 2922 8/PG 2
WGK Germany	2
RTECS	UB6450000
FLUKA BRAND F CODES	27
TSCA	T
HS Code	29055910
Hazard Note	Corrosive
Hazard Class	8
Packing Group	II
Toxicity	LD50 orally in Rabbit: 1500 mg/kg

Sevoflurane USP Related Compound C - Reference

Reference

1. Zhang Li Ling, Gao Tingting, Chen Shi Yu, etc. Preparation and characterization of oriented Poly (ε-caprolactone) micro/nanofibers by electrospinning [J]. Journal of Nantong University (Natural Science Edition), 2019, v.18;No.68(01):54-60 81.
2. Hao Xuyi, Loth, Cheng Shuyi, etc. Effect of danggui Shaoyao San on copper ion-mediated aggregation of Aβ in AD cell model [J]. Chinese Journal of Experimental prescriptions, 2019, 25(06):53-59.
3. Liu et al Xiao-Qi [IF = 5.162]. "Sodium tanshenone IIA sulfonateprotectsagainst Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells." Int J Biol Macromol. 2020 May;151:47

Sevoflurane USP Related Compound C - Introduction

Hexafluoroisopropanol is a special fluorine-containing material with high density, low viscosity and low surface tension. It is transparent under ultraviolet light (<2000A) and has a low refractive index. It can be miscible with water or most organic solvents in any proportion, but it is insoluble in long-chain alkanes. Solubility in water: 1000g/L (25°C)

Last Update：2022-10-16 17:30:11

Sevoflurane USP Related Compound C - Reference Information

LogP	1.5 at 25℃
surface tension	67.1mN/m at 1g/L and 19.8 ℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Overview	hexafluoroisopropanol (HFIP) is a viscous, pungent, colorless liquid. It is an ideal solvent for dissolving polyamides and esters and can be used for the analysis of nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluate to reduce aggregation of the sample. Although HFIP has a certain viscosity, its boiling point is very low, and it is usually required to analyze at 40°C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent, which makes the calibration curve of mixed column column become nonlinear. Therefore, Agilent has developed a special chromatography column for this solvent-PL HFIPgel chromatography column, which has a porous structure that is not affected by the solvent.
Application	hexafluoroisopropanol (HFIP) is an important fluorine-containing fine chemicals, it can be used to prepare various fluorine-containing chemicals such as fluorine-containing surfactants, fluorine-containing emulsifiers, fluorine-containing medicines and the like, or as a good solvent. The efficiency of rhodium (I)-Catalyzed [4 2] intramolecular cycloaddition reaction of ether-bound alkynyl dienes and [5 2] cycloaddition reaction of alkynyl vinyl cyclopropane can be improved; liquid Phase peptide chemical solvents; Highly soluble solvents for peptides and peptide intermediates; For analysis of various polymers.
Application	hexafluoroisopropanol (HFIP) is a new type of fluorine-containing compound, which is a highly polar solvent, it is easy to mix with water and many organic solvents, has good thermal stability, and has good transmittance to ultraviolet light. These properties enable HFIP to be an ideal solvent in many polymerization systems: HFIP is an intermediate for use in pharmaceuticals, for the synthesis of the inhaled anesthetic sevoflurane, and for the synthesis of Agrochemicals: HFIP can be used as a solvent detergent in electronic aspects: HFIP can dissolve a large part of the polymer, such as polyester, polyamide, polyacrylonitrile, polyacetal and hydrolyzed polyvinyl Ester, etc, because of this property, it can be used in the analysis and as a regeneration agent for the reuse of high polymers. hexafluoroisopropanol can be used for the preparation of fluorine-containing surfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals and other high-end chemicals, and as a solvent or cleaning agent for the Electronic Industry fluorinated solvents, the efficiency of rhodium (I)-Catalyzed [4 2] intramolecular cycloaddition reaction of ether-bound alkynyl dienes and [5 2] cycloaddition reaction of alkynyl vinyl cyclopropane can be improved; liquid Phase peptide chemical solvents; Highly soluble solvents for peptides and peptide intermediates; For analysis of various polymers
synthesis method	hexafluoroacetone (HFA, hexafluoroace-tone) catalytic hydrogenation reduction synthesis is usually used, and gas phase method or liquid phase method can be used. HFA, which is gaseous at normal temperature, is reacted with excess hydrogen in a tubular reactor under the action of a catalyst. The gas phase method has a fast reaction speed, but the reaction temperature is higher, and the side reaction is easy to occur. HFA combines with water to form hydrates with different water. The catalytic hydrogenation reaction of HFA hydrate in liquid phase can be carried out at lower temperature. The preparation of HFIP by catalytic reduction method requires the use of expensive catalysts, and HFA often contains a small amount of impurities such as hydrogen fluoride and hydrogen chloride, which easily leads to catalyst poisoning, thereby increasing the cost and reducing the reaction selectivity. 45kg of hexafluoroacetone hydrate (containing 1% catalyst) was input into a 50L reaction kettle, and the vacuum-nitrogen and nitrogen-hydrogen replacement were carried out successively. Hydrogen is introduced to normal pressure, heated to 100 ° C., stirring speed 30 rpm, hydrogen is introduced to 1MPa, and the reaction is carried out at constant pressure until there is no pressure drop for 1 hour. Reduce temperature and pressure, press out the material and filter.

Last Update：2024-04-09 20:48:19

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Sevoflurane USP Related Compound C

1,1,1,3,3,3-Hexafluoro-2-propanol

CAS: 920-66-1

Molecular Formula: C3H2F6O

Sevoflurane USP Related Compound C - Names and Identifiers

Sevoflurane USP Related Compound C - Physico-chemical Properties

Sevoflurane USP Related Compound C - Risk and Safety

Sevoflurane USP Related Compound C - Reference

Sevoflurane USP Related Compound C - Introduction

Sevoflurane USP Related Compound C - Reference Information

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Sevoflurane USP Related Compound C Request for Quotation

1,1,1,3,3,3-Hexafluoro-2-propanol

CAS: 920-66-1

Molecular Formula: C3H2F6O

Sevoflurane USP Related Compound C - Names and Identifiers

Sevoflurane USP Related Compound C - Physico-chemical Properties

Sevoflurane USP Related Compound C - Risk and Safety

Sevoflurane USP Related Compound C - Reference

Sevoflurane USP Related Compound C - Introduction

Sevoflurane USP Related Compound C - Reference Information

Supplier List

Sevoflurane USP Related Compound C